Biogenic Amines

Sepsis is the most serious infectious consequence causing high mortality. In severe cases, sepsis is usually combined with hypotension and hypo-perfusion resulting in organ dysfunction syndrome. The pathogenesis of sepsis involves an excessive production of pro-inflammatory cytokines in response to microbial secretion of chemicals such as lipopolysaccharide, lipoteichoic acid, or protein exotoxins, leading to a cytokine storm. Dopamin (DA) modulatory eff ect on LPS-induced blood cytokines-producing cells is mediated mainly by D2-DAR (D2/ D3/D4) through enhancing immune cells migration and extravasation into tissues. Furthermore, DA selectivity on cytokines modulation is tissue specific, mediated by the type of DAR expressed and on the immune cells lodged in each tissue.

Khalid Z. Matalka et al. BIA 25(3), 2011

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Vol. 25 - Nr. 3 - 2011

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