Biogenic Amines

Sepsis is the most serious infectious consequence causing high mortality. In severe cases, sepsis is usually combined with hypotension and hypo-perfusion resulting in organ dysfunction syndrome. The pathogenesis of sepsis involves an excessive production of pro-inflammatory cytokines in response to microbial secretion of chemicals such as lipopolysaccharide, lipoteichoic acid, or protein exotoxins, leading to a cytokine storm. Dopamin (DA) modulatory eff ect on LPS-induced blood cytokines-producing cells is mediated mainly by D2-DAR (D2/ D3/D4) through enhancing immune cells migration and extravasation into tissues. Furthermore, DA selectivity on cytokines modulation is tissue specific, mediated by the type of DAR expressed and on the immune cells lodged in each tissue.

Khalid Z. Matalka et al. BIA 25(3), 2011


Vol. 25 - Nr. 3 - 2011


Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression
Michael Maes, Ivanka Mihaylova, Marta Kubera, Marc Uytterhoeven, Nicolas Vrydags, Eugene Bosmans

Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain
Karen M. Ashe, Wan-Ling Chiu, Ahmed M. Khalifa, Antoine N. Nicolas, Bonnie L. Brown, Randall R. De Martino, Clayton P. Alexander, Christopher T. Waggener, Krista Fischer-Stenger, Jennifer K. Stewart

Dopamine selectively modulates lipopolysaccharide-induced TNF-alpha, IFN-gamma and IL-10 within mice tissues
Khalid Z. Matalka, Lama J. Attallah, Nidal A. Qinna, Tawfiq Alhussainy

Corticotropin-releasing factor (CRF) over-expression down-regulates hippocampal dopamine receptor protein expression and CREB activation in mice
Maki Kasahara, Lucianne Groenink, Berend Olivier, Zoltán Sarnyai

A neuroeconomic theory of rational addiction and nonlinear time-perception
Taiki Takahashi

The effects of siRNA-mediated RGS4 gene silencing on the whole genome transcription profile: implications for schizophrenia
Monika Vrajová, Soňa Peková, Jiří Horáček, Cyril Höschl