Biogenic Amines

Stimulation of 5-HT1A receptor with 8-OH-DPAT decreased frequency of GABAergic synaptic event in control rats without early postnatal FS (Non-FS), whereas 8-OH-DPAT did not change the frequency in 2w-FS group. 8-OH-DPAT did not change the amplitude of GABAergic synaptic events neither in Non-FS nor 2w-FS group. It was indicated that aversive stress exposure during the early postnatal period decreases 5-HT1A receptor-mediated inhibition of GABAergic mechanisms in adult rat mPFC. Early postnatal 2w-FS attenuated 5-HT1A control of GABAergic regulation which may contribute to abnormal behavioral response in adult rats.

Shinichi Kimura et al. BIA 25(4), 2011

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Vol. 25 - Nr. 4 - 2014

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Attenuation of 5-HT1A regulation in medial prefrontal cortex GABA system of early postnatal-stressed rats
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The selective serotonin re-uptake inhibitors / serotonin and noradrenaline re-uptake inhibitors in pregnancy: possible unfavorable effects on fetal and neurobehavioral development
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