Biogenic Amines

Journal was founded by Professor H. Parvez in 1981, is a peer-reviewed, international interdisciplinary journal integrating the publication of all aspects of research on biogenic amines and amino acid transmitters, their relating compounds and their interacting phenomena. The journal fulfils this aim by publishing regular research papers and short communications.

Indexed/Abstracted in: Biochemistry & Biophysics Citation Index; Biological Abstracts; BIOSIS; Chemical Abstracts; Chemical Industry Notes; Chemical Titles; EMBASE; Exerpta Medica; Index to Scientific Reviews; Inpharma Weekly; Neuroscience Citation Index; Nutrition Abstracts and Reviews; Reactions Weekly.


It is understood that material submitted to the Journal has not been published previously in printed or electronic format and is not under consideration by another publication or electronic medium. All manuscripts submitted for publication should be written in clear, plain English (American or British English spelling), and APPROVED by a native English speaker in case that the correspondent author is not. Biogenic Amines undertakes no language correction.
The correctness of the English language throughout the whole manuscript is entirely the responsibility of the authors. The papers with insufficient English language will be rejected by the Editor-in-Chief immediately after submission, and will be returned to the author without further processing.
All authors must give a signed consent for publication in a letter submitted with the manuscript.


Authors of research articles should disclose any financial arrangement they may have with a company whose product figures prominently in the submitted manuscript or with a company making a competing product. Journal policy requires that reviewers, associate editors,editors, and senior editors reveal in a letter to the Editor-in-Chief any relationships that they have that could be construed as causing a conflict of interest with regard to a manuscript. The letter should include a statement of any financial relationships with commercial companies involved with a product under study.

Financial Disclosure (select relevant items)

(A) I certify that all my affiliations (relationships) with or financial involvement (eg, employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, royalties) with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript are completely disclosed below or in an attachment (or separate sheet).
(B) I certify that all financial and material support for this research and work are clearly identified in the manuscript and financial relationships are separated into those relevant to the subject matter or materials discussed in this manuscript and all professional financial relationships during the period from inception of the work until its publication are revealed (Acknowledgement section).
(C) I have no financial interest in this manuscript and no affiliations (relationships) to disclose.
Each author must read and sign the statement on financial disclosure. If necessary, photocopy this document to distribute to coauthors for their signatures. Please return all copies to Biogenic Amines by fax: + 44-705-347-0739. Alternatively can scanned copies be sent together with the submission.

ALL MANUSCRIPTS must be sent to the Editor-in-Chief by email only (
The final acceptance of all papers for publication in the Biogenic Amines is subject for Chief
Editor’s decision.


No limitations to the total length of their paper, independently of the category (Original papers, Review papers, Clinical Reports, Case Reports, etc) will be applied. Manuscripts should be typed double-spaced on numbered pages and conform to the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals.” Two manuscript pages is approximately one printed page.


All submitted manuscripts are reviewed initially by the Editor-in-Chief. Those manuscripts with insufficient priority for publication are rejected promptly. Other manuscripts are sent to relevant senior scientists for RAPID peer review. The identities of both peer-reviewers and authors are kept confidential. The comments by the reviewers may be conveyed to the authors by the Editor, at his discretion.
Manuscripts are reviewed with due respect for the author’s confidentiality. At the same time, reviewers also have rights to confidentiality, which are respected by the editor. The editor ensures both the authors and the reviewers that the manuscripts sent for review are privileged communications and private intellectual property of the author.
When submitting a manuscript for consideration for publication, authors may suggest the names of potential reviewers of their choice. If an author for any reason wishes to withdraw his/her submitted manuscript from publication, the editor will always respect this wish unless the submitted and accepted manuscript has already passed publishing procedures. The original material of rejected articles will be returned to the authors.


The intellectual content of the paper is the responsibility of the authors. The Editors and the Publisher accept no responsibility for the opinions and statements of the authors. While every effort will be made by the Editors and the Publisher to avoid inaccurate and misleading data, they accept no liability whatsoever for the consequence of inaccurate information. The authors undertake to keep the Editor and the Publisher fully and effectually indemnified against any liability of claims that may arise from the publication of inaccurate and/or misleading data.


It is a condition of publication that the authors transfer the world copyright of their manuscripts to the Biogenic Amines. All manuscripts should therefore be accompanied by a signed statement that the article is original, is not under consideration or has not been previously published in another journal. Nevertheless, authors will be entitled to publish any part of their paper elsewhere without permission, provided the usual acknowledgments and reference to the ORIGINAL source. Authors will be notified if a request to publish a part or whole of their paper is received. Illustrations, figures, tables or quotations from other publications are already copyrighted and can be reproduced only with written permission from the copyright owner. Written permission to use these should accompany the manuscript.


The Editors and the Publisher support the principles of the Declaration of Helsinki of 1975, as revised in 1983, and expect that the authors of papers submitted to the Journal will have obtained ethical consent and followed those legal and regulatory requirements for human experimentation with drugs, including informed consent, according to procedures which apply in their institution and country. When reporting experiments on animals, indicate whether the institution’s or a national research council’s guide for, or any national law on, the care and use of laboratory animals was followed.


Manuscripts should be typed on numbered pages and conform to the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” except the Reference section (see below).
The pages should be numbered consecutively, beginning with the Title page. The sections of the manuscript should be in following sequence: Title page, Abstract (structured for Original papers and non-structured for Review Articles), Key words, Abbreviations, Main text (Introduction, Material and methods, Results and Discussion), Acknowledgments, References, Tables and Figures.
Particular attention should be taken to ensure that the manuscript adheres to the Instructions for Authors of the Biogenic Amines in all respects. The use of footnotes is not permitted (numbered comments/footnotes can be added at the end of the main text, before the Reference section).
It is very important that all the text is typed without extra spaces between words and that all text within a paragraph is typed without extra carriage returns between the lines. To make a new paragraph, only a carriage return is allowed (tabs allowed for numbered or bullet lists). For tables, see TABLES.
The Editors reserve the right to alter manuscripts whenever necessary to make them conform to the stylistic and bibliographic conventions of the Biogenic Amines.


Title page of the manuscript should contain:
1. The title itself.
2. The name(s) of the author(s): first name(s) spelled out, family name and highest academic degree.
3. Author’s Affiliations: The name(s) of the department(s) or institution(s) from which the study originated.
4. Corresponding Author: The name and full address, including telephone and fax numbers, e-mail address(es) and other useful information of the corresponding author. The authors are obliged to inform the publisher immediately about any change of their fax, telephone, e-mail and ordinary mail address by e-mail:
5. A “running headline,” a maximum of 40 characters, including word spaces.


Abstract and Key words follow directly after the Title page (no extra page) A structured abstract (Original Articles) and non-structured abstract (Review papers) not exceeding 250 words should state what was done, including objectives, design, setting, results, the main findings, conclusions, and how the work was interpreted. Additional headings may be used. At least 5 to 10 key words should be used, which correspond to MESH headings by Medline. The key words should be separated by semicolons. The key words will be included in the Subject Index of the volume.The next section can start directly after this on the same page.


List of abbreviations and symbols used and spell them out in full. Abbreviations and symbols must be standard, and SI units (The International System of Units) should be used throughout. Drugs should be described by their official names, but trade names should be indicated in brackets the first time a drug is quoted in the main text.


The text is conventionally divided into sections headed: Introduction, Material and methods, Results and Discussion. Lengthy papers may require subheadings for clarification.


State clearly the purpose of the paper. Do not review the subject extensively and give only pertinent references.


Describe your selection of the observational subjects (patients or laboratory animals, including controls) clearly. Describe the study population in detail. Identify the methods and procedures in sufficient detail to allow other workers to reproduce the results. If the methods used are new or substantially modified, describe them and state their limitations.
When reporting research on human beings, the authors must include an assurance that the work was approved by a medical ethics committee and that the subjects gave their informed consent to participate. (See Ethics.)
When reporting experiments on animals, indicate whether the institution’s or a national research council’s guide for, or any national law on, the care and use of laboratory animals was followed. (See Ethics.)


Do not repeat in the text all the data displayed in the tables or illustrations; only important observations should be emphasized or summarized.


Emphasize only the new and important aspects and conclusions of the study, including the implications and the limitations of the findings and their relation to other relevant studies. The conclusions should be clearly linked with the objectives of the study. Avoid unqualified statements and conclusions that are not supported by the data.
Do not claim priority, and do not allude to work in progress. State new hypotheses when warranted, but clearly label them as such. Recommendations, when appropriate, may be included.


Describe statistical methods with enough detail to enable a knowledgeable reader with access to the original data to verify the reported details. The design of the study and the data sources should be clearly identified. The statistical methods used should be described so that it is clear which method was used and where. Give relevant references and additional details if nonstandard methods or analyses have been applied. The basic principle is to supply sufficient information about design and analysis to allow the research to be repeated by someone else. The presentation of the analysis should include relevant summaries of the data, not just the results of significance testing. The use of confidence interval is encouraged.


Responsibility for the accuracy of bibliographic citations lies entirely with the authors. Citations in the text:
Please ensure that every reference cited in the text is also present in the reference list (and vice versa). Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references are included in the reference list they should follow the standard reference style of the journal and should include a substitution of the publication date with either “Unpublished results” or “Personal
communication”, Citation of a reference as “in press” implies that the item has been accepted for publication.
All citations in the text should refer to:
1. Single author: the author’s name (without initials, unless there is ambiguity) and the year of publication;
2. Two authors: both authors’ names and the year of publication;
3. Three or more authors: first author’s name followed by “et al.” and the year of publication.
Citations may be made directly (or parenthetically). Groups of references should be listed first alphabetically, then chronologically.
Examples: “reports and open studies are available (Norton, 2000; Edwards et al. 2001; Krusz & Stillman, 2001). Mathew et al. (2000) used a fixed and relatively low dosage of valproate and accomplished ...”
In the Reference List:
References should be numbered and arranged first alphabetically and then further sorted chronologically if necessary. More than one reference from the same author(s) in the same year must be identified by the letters “a”, “b”, “c”, etc., placed after the year of publication. The titles of journals should be abbreviated according to the style used in the Index Medicus.

Examples of the correct form of references:SEE LAST PAGE!

1. Standard journal article List all authors when six or less. When seven or more, list only the first six and add et al.
Example: Parkin DM, Clayton D, Black RJ, Masuyer E, Friedl HP, Ivanov E, et al (1996). Childhood leukaemia in Europe after Chernobyl: 5 year follow-up. Br J Cancer. 73: 1006–1012.
If the language is not English, add the translated title in brackets, e.g. Swedin G (1979). Transkutan elektrisk nervstimulering som smärtlindring vid förlossning. [(Transcutaneous electrical nerve stimulation for analgesia in childbirth.) (In Swedish with English abstract.)] Läkartidningen. 776: 1946–1948.
2. Books and other monographs
a/ Personal author(s): Ringsven MK, Bond D (1996). Gerontology and leadership skills for nurses. 2nd ed. Albany (NY): Delmar Publishers.
b/ Editor(s) as author(s): Norman IJ, Redfern SJ, editors (1996). Mental health care for elderly people. New York: Churchill Livingstone.
c/ Chapter in a book: Phillips SJ, Whisnant JP (1995). Hypertension and stroke. In: Laragh J Brenner BM, editors. Hypertension: pathophysiology, diagnosis, management. 2nd ed. New York: Raven Press. p. 465–478.
d/ Conference proceedings: Kimura J, Shibasaki H, editors (1996). Recent advances in clinical neurophysiology. Proceed ings of the 10th International Congress of EM and Clinical Neurophysiology; Oct 15–19, 1995; Kyoto, Japan. Amsterdam: Elsevier.
e/ Conference paper: Bengtsson S, Solheim BG (1992). Enforcement of data protection, privacy and security in med ical informatics. In: Lun KC, Degoulet P, Piemme TE, Rienhoff O, editors. MEDINFO 92. Proceedings of the 7th World Congress on Medical Informatics; Sept 6–10, 1992; Geneva, Switzerland. Amsterdam: North-Holland. p. 1561–155.
f/ Dissertation: Kaplan SJ (1995). Post-hospital home health care: the elderly’s access and utilization (dissertation). St. Louis (MO): Washington Univ.

TABLES AND FIGURES (Figures, illustrations, graphs, etc.)

Tables and Figures should be numbered consecutively and provided with a concise title and legend. Be sure that each table and figure is cited in the text. All tables and figures should be specifically referred to in the text, e.g. Table 3, Figure 3. Figures/illustrations, etc. must send as a high quality scan (.tiff, .eps or .jpg in high resolution, original Illustrator file .ai or PowerPoint file), electronically by email. All figures (figures, illustrations, photographs, representational drawings, graphs, etc.) must be professionally executed; freehand or typewritten lettering is unacceptable.
Figures and Tables including the legends should be placed at the end of the document or in a separate file (not inserted in the main text).


If authors wish to have their figures, tables, or other illustrations to be published in color, for every color page EUR 550.00 (within Europe) or USD 650.00 (outside of Europe) will be charged.
Figures must be sent electronically as separate attachments:
a/ PC compatible Adobe Illustrator 9.0 and 6.0x .AI files or .EPS files (for Mac users .eps) with fonts included in the file (not converted to vector/outline illustration); at the same time the original program files used for illustrations (figures) should also be attached (even original Mac files); as well as .PDF files if possible. Bitmap raster images as .TIF, BMP, GIF or .EPS are accepted if the resolution 300 dpi for published figure size is provided. Files can be compressed with WinZip. JPG files are accepted if saved in high quality compression only.
b/ Excel and PowerPoint files are accepted (PC compatible) as separate files by email.
All exceptions to the above should be agreed upon after contact with our Art Director ( or Publisher (


The scientific and material contributions of others to the work should be acknowledged. Any grant supports should be listed and permission for reproduction of published material acknowledged. Authors are responsible for obtaining written permission from anyone acknowledged by name. The acknowledgments will be published as an appendix to the text.


Before publication the correspondent author will receive a copy of the final version of the paper, which should be read carefully for errors and returned promptly. Proofs will be sent for the correction of typographic errors only. No other changes will be accepted. Proofs not returned within 7 days will be considered as approved by the author(s).


This Journal encourages the submission of important works by young investigators, researchers and practitioners. In this section the Editor wishes to recognize innovative research conducted during graduate and postgraduate studies. Each doctoral thesis or dissertation should contain an abstract and provide a concise synopsis (10 manuscript pages maximum) of the major findings presented in the final version.


The Biogenic Amines has a section carrying comments, questions, or criticism about articles that have been published and where the original authors can respond. This section takes the form of Letters to the Editor, where also other topics and views from readers may be published and discussed.


Monographs or series of articles that have undergone regular scientific review, university approved theses, conference proceedings, symposia on related issues or topics, etc. may be printed as supplements to the Neuroendocrinology Letters. Supplements are published as a separate issues of the Journal and are negotiated in advance with the Editor-in-Chief, and must be prepaid prior to publication. The Supplements are not automatically included in the subscription price, but can be purchased separately at


Instead of Reprints, a print-quality PDF for unlimited use can be ordered by the author(s) for the price of EUR (Europe) 200.00 / USD 250.00.


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Correspondence and information:,
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OBJECTIVES: The distribution of serotonin (5-HT) and its effect on insulin and glucagon secretion were investigated to examine whether there are changes in the pattern of distribution and effect of 5-HT after the onset of experimental diabetes.
METHODS: The pattern of 5-HT and its effect of insulin and glucagon secretion was examined using immunohistochemical and radioimmunoassay techniques, respectively.
RESULTS: 5-HT was demonstrated mainly in the neural elements of the pancreas. 5-HT-containing fine varicose nerve fibers were discerned in the wall of blood vessels and pancreatic ducts. 5-HT-containing nerves were also observed in the periacinar and periinsular regions of normal pancreas. The pattern or intensity of the distribution of serotonergic nerves did not change after the onset of diabetes. The perivascular, periductal, periacinar and periinsular regions of diabetic pancreas all contained 5-HT positive nerves. 5-HT elicited marked increases in insulin secretion from normal pancreas but had an inhibitory effect on insulin secretion from diabetic pancreatic tissues. In contrast, 5-HT inhibited glucagon secretion from normal pancreatic tissue fragments but stimulated glucagon release from diabetic pancreatic tissue fragments.
CONCLUSION: 5-HT is well distributed in normal and diabetic pancreatic tissues and has stimulatory effects on insulin secretion from normal pancreas and glucagon secretion from diabetic pancreas. This result indicates that although 5-HT may help in the maintenance of the blood sugar level in normal pancreas by increasing insulin secretion and decreasing glucagon secretion, it may also aggravate the hyperglycemia observed in diabetes mellitus and hence exacerbate the symptoms of hyperglycemia in poorly controlled diabetes mellitus.


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3 Hellerstrom C, Swenne I, Andersson A (1988). Islet cell replication and diabetes. In: Lefebvre PJ, Pipeleers DG, editors. The pathology of the endocrine pancreas in diabetes. Berlin: Springer-Verlag.

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